Zifam Dovaspin injection

 

Zifam Dovaspin InJection

Composition

Each ml contains:

Drotaverine HCl           20 mg

Absolute Alcohol BP  8% v/v

Water for injection BP      q.s.

 

Indications / Uses

Spastic conditions of the gastrointestinal tract, irritable bowel syndrome.

Biliary colics and spastic conditions of the biliary tract: Cholecystolithiasis, cholecystitis, cholangitis. Renal colics and spastic conditions of the urogenital tract: Nephrolithiasis, ureterolithiasis, pyelitis, cystitis. Spastic conditions of the uterus: Dysmenorrhea, imminent abortion, uterine tetanus.

 

Dosage / Direction for Use

1 to 2 ampoules, intramuscularly or subcutaneously, 1-3 times daily or as directed by the Physician.

For the management of acute stone colics: 1 or 2 ampoules by slow intravenous injection or as directed by the Physician.

 

CONTRAINDICATIONS

Drotaverine is contraindicated in conditions like Cardiac insufficiency, renal insufficiency, hepatic insufficiency, Av block of ii & iii degree.

 

SPECIAL PRECAUTIONS

Exercise caution in patients with renal/hepatic/cardiac dysfunction,

pregnancy, lactation.

 

INTERACTIONS

Concomitant therapy of Drotaverine with Levodopa may decrease the anti-Parkinson effect of Levodopa.

 

PREGNANCY & LACTATION

There is no known case of teratogenicity in animal studies. However, the use of Drotaverine should be avoided during pregnancy and lactation.

SIDE EFFECTS

In rare cases nausea and vomiting may occur. Arterial blood pressure may drop following too rapid intravenous injection. Flushing of face, perspiration, tachycardia, hyperpnoea may be found rarely.

 

Storage

Store at temperature not more than 30°C. Protect from light.

 

DESCRIPTION

Drotaverine is a spasmolytic agent which acts directly on smooth muscle cells by adsorption on the cell surface. Drotaverine inhibits the phosphodiesterase enzyme which leads to an increase of the cAMP level producing smooth muscle cell relaxation. It is thought that Drotaverine also inhibits the initial calcium uptake of the cell. Drotaverine is characterized by a rapid onset of action which is very advantageous in cases of acute painful spastic conditions. Because of its direct action on smooth muscle, Drotaverine does not affect the autonomic nervous system. Therefore, Drotaverine is free of the side effects associated with anticholinergic antispasmodics and can be used in glaucoma and prostatic hypertrophy.In addition to its spasmolytic and vasodilatory actions, Drotaverine elicits a selective blockage of cardiac beta receptors.

 

MIMS Class

Antispasmodics

 

ATC Classification

A03AD02 – drotaverine ; Belongs to the class of papaverine and derivatives. Used in the treatment of functional bowel disorders.

 

Presentation / Packing

A carton containing 10 ampoules of 2 ml each.