Each BECEF vial contains:
Ceftriaxone Sodium USP (Sterile)
equivalent to Anhydrous Ceftriaxone 1.0g
Ceftriaxone is bactericidal. Like other betalactams, Ceftriaxone kills bacteria by preventing their cell wall synthesis. Apart from its antimicrobial activity ceftriaxone has no clinical or pharmacological effects on any system in the body. Cerftiaxone is bactericidal at concentrations easily achievable in the plasma and tissues. It has also been suggested that betalactams may also inhibit protein and bacterial DNA synthesis.
Infections of the respiratory and urinary tracts, skin and soft tissues, bones and joints.Serious bacterial infections with bacteraemia and septicaemia, Bacterial meningitis, pelvic inflammatory disease, STD and surgical prophylaxis.
Known Hypersensitivity to cephalosporins.Hyperbilirunemic neonates especially prematures.
Becef may be administered intravenously or intramuscularly.
Do not use diluents containing calcium, such as Ringer’s solution or Hartmann’s solution,
Children– 50 to 75 mg/kg/day up to a maximum of 2g/day. Meningitis 100 mg/kg/day up to 4g/day.
Reconstitute Becef 1 g in 9.6 ml of appropriate diluentfor IV administration (or)1 g in 3.6mL of diluent for IM. The diluents may be sterile water for injection, 0.9% sodium chloride or 5% dextrose. Deep intragulteal muscle injection is recommended to minimize pain.
Ceftriaxone is generally well tolerated. Adverse reactions are usually mild and transient and drug discontinuations has been required in about 1% of patients.
Hypersensitivity to cephalosporin and/or penicillins should be looked before starting Ceftriaxone. If the former is known, Ceftriaxone should not be given.
One case of acute overdosage has been reported in which 100 times the recommended dose of Ceftriaxone was given intrathecally.
Alcohol: A possible disulfiram-like reaction may occur with alcohol, though the potential for this and hypoprothrombinaemia is low because of the N-methylthiotetrazole side chain present in cephamandole.
Box containing 1g Becef vial with water for injection.