Oloxin
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- မြန်မာ
Ofloxacin
PRESENTATION: Tablet 200mg x 10’s
DESCRIPTION
OLOXIN® (ofloxacin tablets) Tablets is a synthetic broad-spectrum antimicrobial agent for oral administration. Chemically, ofloxacin, a fluorinated carboxyquinolone, is the racemate, (±)-9-fluoro-2,3-dihydro-3-methyl-10-(4-methyl-1-piperazinyl) -7-oxo-7H-pyrido[1,2,3-de]-1,4-benzoxazine-6-carboxylic acid.
Its empirical formula is C 18 H 20 FN 3 O 4 , and its molecular weight is 361.4.
INDICATIONS AND USAGE
OLOXIN (ofloxacin tablets) Tablets are indicated for the treatment of adults with mild to moderate infections (unless otherwise indicated) caused by susceptible microorganisms in the infections listed below.
CONTRAINDICATIONS
OLOXIN (ofloxacin) is contraindicated in persons with a history of hypersensitivity associated with the use of ofloxacin or any member of the quinolone group of antimicrobial agents.
PRECAUTIONS
Pregnancy: There are no adequate and well-controlled studies in pregnant women. Ofloxacin should be used during pregnancy only if the potential benefit justifies the potential risk to the fetus.
Nursing Mothers:
In lactating females, a single oral 200-mg dose of ofloxacin resulted in concentrations of ofloxacin in milk that were similar to those found in plasma. Because of the potential for serious adverse reactions from ofloxacin in nursing infants, a decision should be made whether to discontinue nursing or to discontinue the drug, taking into account the importance of the drug to the mother.
Pediatric Use:
Safety and effectiveness in pediatric patients and adolescents below the age of 18 years have not been established.
ADVERSE REACTIONS
Gastrointestinal: nausea, vomiting, diarrhea, anorexia
Neurological: headache, dizziness, insomnia, visual disturbance
Allergic reaction: pruritus, fever, rash
DOSAGE AND ADMINISTRATION
The usual dose of OLOXIN (ofloxacin tablets) Tablets is 200 mg to 400 mg daily usually for 5-7 days depending on the severity and the nature of infection.
Patients with Impaired Renal Function: No dosage adjustment is needed if creatinine clearance >50mL/min. In patients with impaired renal function, after a normal initial dose, dosage should be adjusted as follows: Creatinine clearance – 20 to 50mL/min – 100 to 200mg every 24 h, <20mL/min – 100mg every 24h.
