Taxim Injection
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COMPOSITION
Each vial contains:
Cefotaxime Sodium USP equivalent to Cefotaxime….250 mg, 500mg, and 1g.
DESCRIPTION
TAXIM (Cefotaxime) Injection is a semi synthetic, broad spectrum cephalosporin antibiotic. It is an odourless, white to slightly cream coloured powder. TAXIM (Cefotaxime) is freely soluble in water, insoluble in organic solvents.
INDICATIONS & USAGE
Cefotaxime is indicated for the treatment of the following severe infections when known or thought very likely to be due to bacteria that are susceptible to cefotaxime:
- Bacterial pneumonia; cefotaxime is not active against bacteria that cause atypical pneumonia or against several other bacterial species that may cause pneumonia, including P. aeruginosa.
- Complicated infections of the kidneys and upper urinary tract.
- Severe infections of the skin and soft tissue
- Gynecologic infections, including pelvic inflammatory disease, endometritis and pelvic cellulitis caused by Staphylococcus epidermidis, Streptococcus species, Enterococcus species, Enterobacter species
- Intra-abdominal infections (such as peritonitis). Cefotaxime should be used in combination with an antibiotic that is active against anaerobes in the treatment of intra-abdominal infections.
- Acute bacterial meningitis (particularly if due to H. influenzae, N. meningitidis, S. pneumoniae, E. coli, Klebsiella spp.)
- Septicaemia infections originating from the lungs, urinary tract, or bowel (in case of gram-negative organisms a combination with another suitable antibiotic should be considered).
- Bone and/or joint infections: Caused by Staphylococcus aureus (penicillinase and non-penicillinase producing strains), Streptococcus species (including S. pyogenes), Pseudomonas species (including P. aeruginosa), and Proteus mirabilis.
Consideration should be given to official guidance on the appropriate use of antibacterial agents.
Prevention:
The administration of cefotaxime preoperatively reduces the incidence of certain infections in patients undergoing surgical procedures (e.g.,
abdominal or vaginal hysterectomy, gastrointestinal and genitourinary tract surgery) that may be classified as contaminated or potentially contaminated.
Contra Indications
TAXIM is contraindicated in patients who have shown hypersensitivity to Cefotaxime Sodium or the Cephalosporin group of antibiotic.
Warning
Psudomembranous Colitis has been reported with the use of Cephalosporins. It is important to consider its diagnosis in patients who develop diarrhoea in association with antibiotic.
Drug Interaction
Increased nephrotoxicity has been reported following concomitant administration of cephalosporin and aminoglycoside antibiotics.
Use in Pregnancy and Lactation
Animals reproductive studies are not always predictive of human response. This drug should not be used during pregnancy only if clearly needed.
Non-teratogenic effects: Use of the drug in women of childbearing potential requires that of anticipated benefit be weighed against the possible risk.
Nursing Mother:Cefotaxime Sodium is excreted in human milk, caution must be exercised when TAXIM is administered to a nursing mother.
Adverse Effects: Normally it is well tolerated drug. The most frequent adverse reactions are:-
a) Injections side inflammation, pain enduration and tenderness after IM injection.
b) Hypersensitivity; Rash, Pruitus, fever and eosinophilia.
c) Gastrointestinal: Colitis, diarrhoea, nausea and vomitting.
d) Less frequent adverse reactions are:-Haemotologic system: Neutropenia, Leukopenia, Eosinophilia, thrombocytopenia and agranulocytosis have been reported.
Genito-urinary system: Moniliasis, Vaginitis.
C N S- system: Headache
Liver: Transient elevations in SGOT,SGPT, serum LDH alkaline phosphate level have been reported.
DOSAGE AND ADMINISTRATION
Taxim be administered IM or IV after reconstitution.
To prevent postoperative infection in contaminated or potentially contaminated surgery: The recommended dose is 1g/ IM or IV
Caesariean Patients: The first dose 1 g is administered I.V. as soon as the umbilical cord is clamped.
The second dose 1 g IV or IM at 6 and 12 hours after the first dose.
Neonates Infants and Children:
Neonates(birth to 1 month) 0-1 week of age: 50mg/kg I.V. of 12 hours.
1-4 weeks of age:50mg/kg I.V. of 8 hours.
PACKING: 250/500mg vial with 5ml amp. of sterile water for injection.
1gm vial (50 vials clinic carton)