Zifam Asist
- ENG
- မြန်မာ
Composition
Each ml contains:
Acetylcysteine USP ………….. 200 mg
Water for injections BP ……… q.s.
Description
Acetylcysteine is the N-acetyl derivative of cysteine used primarily as a mucolytic agent and as intravenous (I.V.) medication in the management of acetaminophen overdose.
Mechanism of Action
Acetylcysteine has been shown to reduce the extent of liver injury following acetaminophen overdose.It is most effective when given early, with benefit seen principally in patients treated within 8-10 hours of the overdose. Acetylcysteine likely protects the liver by maintaining and restoring the glutathione levels, or by acting as an alternate substrate for conjugation with, and thus detoxification of, the reactive metabolite.
Indications
This medication is used as an antidote for acetaminophen overdose to prevent life-threatening liver damage.
Contraindication
Acetylcysteine is contraindicated in patients with hypersensitivity or previous anaphylactic reaction to acetylcysteine or any component of the preparation.
DOSAGE
Pre-Treatment Assessment Following Acute Ingestion:
Obtain a plasma or serum sample to assay for acetaminophen concentration at least 4 hours after ingestion.
If the time of acetaminophen ingestion is unknown:
- Administer a loading dose of ZIFAM ASIST INJECTION immediately.
- Obtain an acetaminophen concentration to determine need for continued treatrment. If the acetaminophen concentration cannot be obtained (or is unavailable or uninterpretable) within the 8-hour time interval after acetaminophen ingestion or there is clinical evidence of acetaminophen toxicity:
- Administer a loading dose of ZIFAM ASIST INJECTION immediately and continue treatment for a total of three doses over 21 hours.
If the patient presents more than 8 hours after ingestion and the time of acute acetaminophen ingestion is known:
- Administer a loading dose of ZIFAMASIST INJECTIONimmediately
- Obtain acetaminophen concentration to determine need for continued treatment
If the patient presents less than 8 hours after ingestion and the time of acute acetaminophen ingestion is known and theacetaminophen concentration is known:
Use the Rumack – Matthewnomogram to determine whether or not to initiate treatment with ZIFAM ASIST INJECTION
Warning & Precautions
Monitor, acute flushing and erythema of the skin may occur, usually associated with the loading dose, often resolves spontaneously despite continued infusion.
Monitor for serious anaphylactoid reactions; infusion may be interrupted until treatment of anaphylactoid symptoms has been initiated.
